ABSTRACT
Objective: To determine Juvenile Arthritis Disease Activity Score in children with juvenile idiopathic arthritis and its association with disease activity
Study Design: Cross sectional analytical
Place and Duration of Study: The study was conducted in the department of Immunology and Serology, the Children Hospital and the Institute of Child Health Lahore, from Jun 2015 to Jun 2016
Material and Methods: All consecutive patients in a period of three months from Jun to Aug who fulfilled the inclusion criteria were enrolled from Out Patient Department and Medical Unit 1. Demographic profile including age and gender were recorded. Type of arthritis was assigned according to ILAR. The severity of the disease of patients was assessed by using the JADAS-27 score at the time of presentation. Statical analysis of data was done on SPSS version 17.0 for obtaining statistical results
Results: Out of 45 patients, 44 percent [n=20] were males and 56 percent [n=25] were females between the age of 3-17 years. polyarthritis was found in 51.1 percent [n=23] followed by oligoarthritis 37.7 percent [n=17] and systemic onset disease 11.1 percent [n=5]. Morning stiffness [97.8 percent] and fever [86.7 percent] were the most common clinical presentations. All patients with systemic onset disease had fever [n=5] followed by skin rash, hepatosplenomegaly and lymphadenopathy. Creactive protein was positive in 30 [66.67 percent] patients. Erythrocyte sedimentation rate was raised in 41 [91.11 percent] patients. Rheumatoid factor [RF] positivity was observed in 12 [26.67 percent] cases. Anti-nuclear antibodies were found positive in 3 [6.66 percent] patients. Out of 45 patients 5 were in clinical remission, 11 were in minimal disease activity and 29 had severe clinical disease activity. Maximum 11 cases of severe disease activity lie between 30-40 JADAS-27 score each for CRP and ESR.
Conclusion: There was significant association between Juvenile Arthritis Disease Activity Score and Clinical Disease Activity. CRP and ESR were proved to be good inflammatory markers in JIA
ABSTRACT
Objective: To assess prevalence of gross and fine motor functional impairments in children with CP
Methods: This cross sectional study was conducted at Department of Developmental and Behavioural Paediatrics, The Children's Hospital and Institute of Child Health, Lahore from October, 2014 to September, 2015. Atotal of 100 CP patients were taken to assess for gross and fine motor functional impairment, using Gross Motor Functional Classification System [GMFCS] and Bimanual Fine Motor Function [BFMF] scales. All data were analyzed using SPSS version 20
Results: In this hospital-based study comprised 100 children with a diagnosis of CP with 2 to 8 years of age were ascertained. The mean age of patients was found as 4.090 +/- 1.672 years. Study group included 32 females and 68 males. GMFCS was found at level I in 5% patients, level II in 18% patients, level III in 16% patients, level IV in 15% patients and level V in 46% patients. The corresponding percentages for BFMF were 21.7% patients, 18% patients, 15% patients, 13% patients and 33% respectively. Among oral musculature problems, drooling was the most common problem [68 %]. Larger proportion of gross motor functional impairment were associated with the spastic type of cerebral palsy [p=0.03], more specifically quadriplegic cerebral palsy [p=0.000]. Also a larger number of patients with fine motor functional impairments were associated with spastic type of cerebral palsy [p=0.009], more precisely quadriplegic cerebral palsy [p=0.000]
Conclusion: It is concluded that quadriplegic spastic CP was the most frequent type that had the worst motor impairment hence making patients functionally dependant in activities of daily livings
ABSTRACT
Objective: the objective of this study is to identify risk factors related to low BMD among patients attending the Centre for Nuclear Medicine [CENUM]
Methods: it was a cross sectional study conducted at the Centre for Nuclear Medicine [CENUM] Mayo Hospital Lahore, from February 2011 to September 2011.A sample of 246 participants aged 50 to 85 years [both male and female] was selected using non probability convenient sampling technique. Magnitude of BMD status was described using T score as WHO criteria. The data was analyzed by using SPSS version 17.Pearson Correlation was applied to find relationship between different quantitative variable. Also, an independent sample T test was applied to see the significant difference
Results: the results have shown that out of 246 participants, 24 [9.8%] were men and 222 were women [90.2%] aged 50-85 yrs. BMD has significant correlation with age, weight and height of the patients [p 0.05 for both Left Hip and lumber spine T score respectively] as compared to other patients. The patients who had low backache also showed low BMD [p
Conclusions: based on the study results it is concluded that low BMD is a wide spread public health problem and it needs due importance